Higly Cited Papers

1734 documents identified in the Top 1% most cited in the world.
Only 50 are listed. Click here to see the full list (it may take a while).


Document Citations 

N Engl J Med. 2001; 344(11):783-792;  Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. .

Slamon, DJ; Leyland-Jones, B; Shak, S; Fuchs, H; Paton, V; Bajamonde, A; Fleming, T; Eiermann, W; Wolter, J; Pegram, M; et. al.  +

3.923  at 31-12-2012  
(4.781 at 17-06-2014)  


N Engl J Med. 2002; 347(13):975-982;  Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. .

Fried, Michael W; Shiffman, Mitchell L; Reddy, K Rajender; Smith, Coleman; Marinos, George; Gonçales, Fernando L; Häussinger, Dieter; Diago, Moises; Carosi, Giampiero; Dhumeaux, Daniel; et. al.  +

3.398  at 31-12-2012  
(4.043 at 17-06-2014)  


Bioinformatics. 2003; 19(18):2496-2497;  DnaSP, DNA polymorphism analyses by the coalescent and other methods .

Rozas, Julio; Sánchez-DelBarrio, Juan C; Messeguer, Xavier; Rozas, Ricardo  +

3.369  at 31-12-2012  
(4.057 at 17-06-2014)  


N Engl J Med. 2001; 344(10):699-709;  Efficacy and safety of recombinant human activated protein C for severe sepsis. .

Bernard, GR; Vincent, JL; Laterre, PF; LaRosa, SP; Dhainaut, JF; Lopez-Rodriguez, A; Steingrub, JS; Garber, GE; Helterbrand, JD; Ely, EW; et. al.  +

3.020  at 31-12-2012  
(3.450 at 17-06-2014)  


J Pathol. 1999; 189(1):12-19;  Human papillomavirus is a necessary cause of invasive cervical cancer worldwide .

Walboomers, JM; Jacobs, MV; Manos, MM; Bosch, FX; Kummer, JA; Shah, KV; Snijders, PJ; Peto, J; Meijer, CJ; Muñoz, N  +

2.965  at 31-12-2012  
(3.774 at 10-10-2014)  


Nature. 2001; 411(6837):599-603;  Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease .

Hugot, JP; Chamaillard, M; Zouali, H; Lesage, S; Cézard, JP; Belaiche, J; Almer, S; Tysk, C; O'Morain, CA; Gassull, M; et. al.  +

2.546  at 31-12-2012  
(2.978 at 17-06-2014)  


Science. 1997; 275(5297):218-220;  Cancer chemopreventive activity of resveratrol, a natural product derived from grapes .

Jang, M; Cai, EN; Udeani, GO; Slowing, KV; Thomas, CF; Beecher, CW; Fong, HH; Farnsworth, NR; Kinghorn, AD; Mehta, RG; et. al.  +

2.350  at 31-12-2012  
(2.931 at 17-06-2014)  


Nature. 1997; 390(6657):249-256;  The complete genome sequence of the Gram-positive bacterium Bacillus subtilis .

Kunst, F; Ogasawara, N; Moszer, I; Albertini, AM; Alloni, G; Azevedo, V; Bertero, MG; Bessières, P; Bolotin, A; Borchert, S; et. al.  +

2.284  at 31-12-2012  
(6.385 at 17-06-2014)  


N Engl J Med. 2003; 348(6):518-527;  Epidemiologic classification of human papillomavirus types associated with cervical cancer .

Muñoz, Nubia; Bosch, F Xavier; de Sanjosé, Silvia; Herrero, Rolando; Castellsagué, Xavier; Shah, Keerti V; Snijders, Peter J F; Meijer, Chris J L M; Int Agcy Res Canc Multicenter Cerv  +

2.163  at 31-12-2012  
(2.844 at 10-10-2014)  


Mol Biol Evol. 2008; 25(7):1253-1256;  jModelTest: Phylogenetic model averaging .

Posada, David  +

1.893  at 31-12-2012  
(3.422 at 17-06-2014)  


Science. 1999; 285(5429):901-906;  Functional characterization of the S-cerevisiae genome by gene deletion and parallel analysis .

Winzeler, EA; Shoemaker, DD; Astromoff, A; Liang, H; Anderson, K; Andre, B; Bangham, R; Benito, R; Boeke, JD; Bussey, H; et. al.  +

1.870  at 31-12-2012  
(2.164 at 17-06-2014)  


Cell. 1999; 97(6):703-716;  Subventricular zone astrocytes are neural stem cells in the adult mammalian brain .

Doetsch, F; Caillé, I; Lim, DA; García-Verdugo, JM; Alvarez-Buylla, A  +

1.822  at 31-12-2012  
(2.153 at 17-06-2014)  


J Clin Oncol. 2000; 18(16):2938-2947;  Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer .

de Gramont, A; Figer, A; Seymour, M; Homerin, M; Hmissi, A; Cassidy, J; Boni, C; Cortes-Funes, H; Cervantes, A; Freyer, G; et. al.  +

1.751  at 31-12-2012  
(1.986 at 17-06-2014)  


Blood. 1997; 89(6):2079-2088;  International scoring system for evaluating prognosis in myelodysplastic syndromes .

Greenberg, P; Cox, C; LeBeau, MM; Fenaux, P; Morel, P; Sanz, G; Sanz, M; Vallespi, T; Hamblin, T; Oscier, D; et. al.  +

1.727  at 31-12-2012  
(2.152 at 17-06-2014)  


Lancet. 2000; 355(9209):1041-1047;  Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial .

Douillard, JY; Cunningham, D; Roth, AD; Navarro, M; James, RD; Karasek, P; Jandik, P; Iveson, T; Carmichael, J; Alakl, M; et. al.  +

1.694  at 31-12-2012  
(1.919 at 17-06-2014)  


Nature. 2006; 444(7118):444-454;  Global variation in copy number in the human genome .

Redon, Richard; Ishikawa, Shumpei; Fitch, Karen R; Feuk, Lars; Perry, George H; Andrews, T Daniel; Fiegler, Heike; Shapero, Michael H; Carson, Andrew R; Chen, Wenwei; et. al.  +

1.678  at 31-12-2012  
(2.117 at 17-06-2014)  


J Clin Oncol. 2003; 21(12):2237-2246;  Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer .

Fukuoka, Masahiro; Yano, Seiji; Giaccone, Giuseppe; Tamura, Tomohide; Nakagawa, Kazuhiko; Douillard, Jean-Yves; Nishiwaki, Yutaka; Vansteenkiste, Johan; Kudoh, Shinzoh; Rischin, Danny; et. al.  +

1.658  at 31-12-2012  
(1.993 at 17-06-2014)  


N Engl J Med. 2005; 353(16):1659-1672;  Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer .

Piccart-Gebhart, Martine J; Procter, Marion; Leyland-Jones, Brian; Goldhirsch, Aron; Untch, Michael; Smith, Ian; Gianni, Luca; Baselga, Jose; Bell, Richard; Jackisch, Christian; et. al.  +

1.657  at 31-12-2012  
(2.113 at 17-06-2014)  


Lancet. 1997; 350(9080):757-764;  Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension .

Staessen, JA; Fagard, R; Thijs, L; Celis, H; Arabidze, GG; Birkenhager, WH; Bulpitt, CJ; deLeeuw, PW; Dollery, CT; Fletcher, AE; et. al.  +

1.608  at 31-12-2012  
(1.758 at 17-06-2014)  


N Engl J Med. 2001; 345(12):870-878;  The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes .

Parving, HH; Lehnert, H; Bröchner-Mortensen, J; Gomis, R; Andersen, S; Arner, P; Irbesartan Patients Type 2 Diabete  +

1.578  at 31-12-2012  
(1.782 at 17-06-2014)  


Nature. 2002; 418(6896):387-391;  Functional profiling of the Saccharomyces cerevisiae genome .

Giaever, Guri; Chu, Angela M; Ni, Li; Connelly, Carla; Riles, Linda; Véronneau, Steeve; Dow, Sally; Lucau-Danila, Ankuta; Anderson, Keith; André, Bruno; et. al.  +

1.569  at 31-12-2012  
(3.008 at 17-06-2014)  


Bioinformatics. 2009; 25(11):1451-1452;  DnaSP v5: a software for comprehensive analysis of DNA polymorphism data .

Librado, P.; Rozas, J.  +

1.534  at 31-12-2012  
(2.905 at 17-06-2014)  


N Engl J Med. 2006; 354(6):567-578;  Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck .

Bonner, James A; Harari, Paul M; Giralt, Jordi; Azarnia, Nozar; Shin, Dong M; Cohen, Roger B; Jones, Christopher U; Sur, Ranjan; Raben, David; Jassem, Jacek; et. al.  +

1.494  at 31-12-2012  
(1.981 at 17-06-2014)  


N Engl J Med. 2002; 346(25):1937-1947;  The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma .

Rosenwald, A; Wright, G; Chan, WC; Connors, JM; Campo, E; Fisher, RI; Gascoyne, RD; Muller-Hermelink, HK; Smeland, EB; Staudt, LM; et. al.  +

1.438  at 31-12-2012  
(1.768 at 17-06-2014)  


N Engl J Med. 2003; 348(11):994-1004;  Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia .

O'Brien, Stephen G; Guilhot, François; Larson, Richard A; Gathmann, Insa; Baccarani, Michele; Cervantes, Francisco; Cornelissen, Jan J; Fischer, Thomas; Hochhaus, Andreas; Hughes, Timothy; et. al.  +

1.424  at 31-12-2012  
(1.688 at 17-06-2014)  


Nature. 2003; 421(6920):231-237;  Systematic functional analysis of the Caenorhabditis elegans genome using RNAi .

Kamath, Ravi S; Fraser, Andrew G; Dong, Yan; Poulin, Gino; Durbin, Richard; Gotta, Monica; Kanapin, Alexander; Le Bot, Nathalie; Moreno, Sergio; Sohrmann, Marc; et. al.  +

1.404  at 31-12-2012  
(2.023 at 17-06-2014)  


Nature. 2006; 444(7117):337-342;  Resveratrol improves health and survival of mice on a high-calorie diet .

Baur, Joseph A; Pearson, Kevin J; Price, Nathan L; Jamieson, Hamish A; Lerin, Carles; Kalra, Avash; Prabhu, Vinayakumar V; Allard, Joanne S; Lopez-Lluch, Guillermo; Lewis, Kaitlyn; et. al.  +

1.273  at 31-12-2012  
(1.743 at 17-06-2014)  


Nat Cell Biol. 2000; 2(2):76-83;  The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression .

Cano, A; Pérez-Moreno, MA; Rodrigo, I; Locascio, A; Blanco, MJ; del Barrio, MG; Portillo, F; Nieto, MA  +

1.262  at 31-12-2012  
(1.556 at 17-06-2014)  


Jama-J Am Med Assoc. 1997; 277(22):1775-1781;  Plasma homocysteine as a risk factor for vascular disease - The European concerted action project .

Graham, IM; Daly, LE; Refsum, HM; Robinson, K; Brattström, LE; Ueland, PM; Palma-Reis, RJ; Boers, GH; Sheahan, RG; Israelsson, B; et. al.  +

1.212  at 31-12-2012  
(1.338 at 17-06-2014)  


Cell. 1997; 91(1):25-34;  Telomere shortening and tumor formation by mouse cells lacking telomerase RNA .

Blasco, MA; Lee, HW; Hande, MP; Samper, E; Lansdorp, PM; DePinho, RA; Greider, CW  +

1.203  at 31-12-2012  
(1.362 at 17-06-2014)  

31.  1.197  at 31-12-2012  
(1.346 at 17-06-2014)  


N Engl J Med. 2005; 352(11):1092-1102;  Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial .

Bresalier, Robert S; Sandler, Robert S; Quan, Hui; Bolognese, James A; Oxenius, Bettina; Horgan, Kevin; Lines, Christopher; Riddell, Robert; Morton, Dion; Lanas, Angel; et. al.  +

1.191  at 31-12-2012  
(1.406 at 17-06-2014)  


Eur Heart J. 2003; 24(11):987-1003;  Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project .

Conroy, RM; Pyörälä, K; Fitzgerald, AP; Sans, S; Menotti, A; De Backer, G; De Bacquer, D; Ducimetière, P; Jousilahti, P; Keil, U; et. al.  +

1.167  at 31-12-2012  
(1.499 at 17-06-2014)  


N Engl J Med. 2009; 360(13):1320-1328;  Screening and Prostate-Cancer Mortality in a Randomized European Study .

Schröder, Fritz H; Hugosson, Jonas; Roobol, Monique J; Tammela, Teuvo L J; Ciatto, Stefano; Nelen, Vera; Kwiatkowski, Maciej; Lujan, Marcos; Lilja, Hans; Zappa, Marco; et. al.  +

1.159  at 31-12-2012  
(1.555 at 17-06-2014)  


Lancet. 1998; 352(9136):1245-1251;  Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II) .

Hacke, W; Kaste, M; Fieschi, C; von Kummer, R; Davalos, A; Meier, D; Larrue, V; Bluhmki, E; Davis, S; Donnan, G; et. al.  +

1.151  at 31-12-2012  
(1.357 at 17-06-2014)  


N Engl J Med. 2006; 355(23):2408-2417;  Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia .

Druker, Brian J; Guilhot, François; O'Brien, Stephen G; Gathmann, Insa; Kantarjian, Hagop; Gattermann, Norbert; Deininger, Michael W N; Silver, Richard T; Goldman, John M; Stone, Richard M; et. al.  +

1.149  at 31-12-2012  
(1.498 at 17-06-2014)  


N Engl J Med. 1998; 338(21):1488-1497;  Inhibition of the platelet glycoprotein IIb/IIIa receptor with tirofiban in unstable angina and non-Q-wave myocardial infarction .

Bazzino, O; Barrero, C; Garre, L; Sosa, A; Aylward, P; Slany, J; Beaudry, P; Bedard, J; DeLarochelliere, R; Nguyen, M; et. al.  +

1.088  at 31-12-2012  
(1.131 at 17-06-2014)  


Bioinformatics. 2005; 21(9):2104-2105;  ProtTest: selection of best-fit models of protein evolution .

Abascal, Federico; Zardoya, Rafael; Posada, David  +

1.084  at 31-12-2012  
(1.423 at 17-06-2014)  


N Engl J Med. 2008; 359(13):1317-1329;  Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke .

Hacke, Werner; Kaste, Markku; Bluhmki, Erich; Brozman, Miroslav; Dávalos, Antoni; Guidetti, Donata; Larrue, Vincent; Lees, Kennedy R; Medeghri, Zakaria; Machnig, Thomas; et. al.  +

1.034  at 31-12-2012  
(1.609 at 17-06-2014)  


N Engl J Med. 2004; 350(23):2343-2351;  Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer .

André, Thierry; Boni, Corrado; Mounedji-Boudiaf, Lamia; Navarro, Matilde; Tabernero, Josep; Hickish, Tamas; Topham, Clare; Zaninelli, Marta; Clingan, Philip; Bridgewater, John; et. al.  +

1.016  at 31-12-2012  
(1.280 at 17-06-2014)  


N Engl J Med. 1998; 339(21):1493-1499;  Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C .

Davis, GL; Esteban-Mur, R; Rustgi, V; Hoefs, J; Gordon, SC; Trepo, C; Shiffman, ML; Zeuzem, S; Craxi, A; Ling, MH; et. al.  +

1.011  at 31-12-2012  
(1.058 at 17-06-2014)  


N Engl J Med. 2005; 352(24):2487-2498;  Bortezomib or high-dose dexamethasone for relapsed multiple myeloma .

Richardson, Paul G; Sonneveld, Pieter; Schuster, Michael W; Irwin, David; Stadtmauer, Edward A; Facon, Thierry; Harousseau, Jean-Luc; Ben-Yehuda, Dina; Lonial, Sagar; Goldschmidt, Hartmut; et. al.  +

994  at 31-12-2012  
(1.239 at 17-06-2014)  


Lancet. 2002; 359(9319):1734-1739;  Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial .

Llovet, Josep M; Real, Maria Isabel; Montaña, Xavier; Planas, Ramon; Coll, Susana; Aponte, John; Ayuso, Carmen; Sala, Margarita; Muchart, Jordi; Solà, Ricard; et. al.  +

973  at 31-12-2012  
(1.262 at 17-06-2014)  


Lancet. 2005; 365(9464):1046-1053;  Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study .

Marin, Jose M; Carrizo, Santiago J; Vicente, Eugenio; Agusti, Alvar G N  +

969  at 31-12-2012  
(1.307 at 17-06-2014)  


Nature. 2006; 441(7091):349-353;  Polycomb complexes repress developmental regulators in murine embryonic stem cells .

Boyer, Laurie A; Plath, Kathrin; Zeitlinger, Julia; Brambrink, Tobias; Medeiros, Lea A; Lee, Tong Ihn; Levine, Stuart S; Wernig, Marius; Tajonar, Adriana; Ray, Mridula K; et. al.  +

966  at 31-12-2012  
(1.209 at 17-06-2014)  

46.  959  at 31-12-2012  
(1.054 at 17-06-2014)  


N Engl J Med. 2004; 350(11):1081-1092;  A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer .

Coombes, R Charles; Hall, Emma; Gibson, Lorna J; Paridaens, Robert; Jassem, Jacek; Delozier, Thierry; Jones, Stephen E; Alvarez, Isabel; Bertelli, Gianfilippo; Ortmann, Olaf; et. al.  +

954  at 31-12-2012  
(1.089 at 17-06-2014)  


N Engl J Med. 2004; 350(10):1005-1012;  The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease .

Celli, Bartolome R; Cote, Claudia G; Marin, Jose M; Casanova, Ciro; de Oca, MM; Mendez, Reina A; Pinto Plata, Victor; Cabral, Howard J  +

948  at 31-12-2012  
(1.277 at 17-06-2014)  


Nature. 2007; 447(7148):1087-U7;  Genome-wide association study identifies novel breast cancer susceptibility loci .

Easton, Douglas F; Pooley, Karen A; Dunning, Alison M; Pharoah, Paul D P; Thompson, Deborah; Ballinger, Dennis G; Struewing, Jeffery P; Morrison, Jonathan; Field, Helen; Luben, Robert; et. al.  +

944  at 31-12-2012  
(1.224 at 17-06-2014)  


Science. 2004; 304(5674):1158-1160;  Hereditary early-onset Parkinson's disease caused by mutations in PINK1 .

Valente, Enza Maria; Abou-Sleiman, Patrick M; Caputo, Viviana; Muqit, Miratul M K; Harvey, Kirsten; Gispert, Suzana; Ali, Zeeshan; Del Turco, Domenico; Bentivoglio, Anna Rita; Healy, Daniel G; et. al.  +

939  at 31-12-2012  
(1.199 at 17-06-2014)